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To view a copy of this licence, visit About this article Cite this article Vniant, M.M., Lu, SC., Atangan, L

PubMed Central PMCID: PMC4296509

Patients with comorbidities, such as depression, anxiety, or sedentary behavior, may experience reduced efficacy.[49] Moreover, over half of the lost weight is often regained after discontinuation.[50] Common side effects include gastrointestinal (GI) symptoms such as nausea, vomiting, and diarrhea,[51] while severe outcomes like pancreatitis or thyroid cancer have not shown significant increases.[52] Notably, weight loss does not always equate to improved health

You may feel full after just a few bites, experience nausea, or struggle to eat enough protein throughout the day

However, assessment of body composition in both of these studies revealed that the absence of GIPR signaling in adipocytes contributes to reduced lean mass, but not fat mass