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1 The two dominant incretins are glucagon-like peptide-1 (GLP-1), secreted by enteroendocrine L cells (located in the ileum and colon), and glucose-dependent insulinotropic peptide (GIP), secreted by K cells (located mainly in the duodenum)

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So this is another area we dont fully understand, but it seems like there are some people who are quite sensitive to the drugs and others who are insensitive to the drugs, and there might be a genetic component to this too, thats a frontier area of science

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