glp 1 agonist vs sglt2 inhibitor Complementary Yet Distinct Roles of GLP-1 Receptor Agonists and Inhibitors in Cardiovascular Risk Reduction Recommendations for SGLT2i versus GLP-1

Liraglutide didnt achieve quite the same level of weight loss

This was not straightforward and took several years to achieve

Notably, two new glucagon-like peptides were identified in intestinal extracts: GLP-1 and GLP-2

One possibility is that since ductal replication is increased with obesity or type 2 diabetes (24), and GLP-1 may amplify this, studies in lean nondiabetic animals may have had a limited propensity to GLP-1induced pancreatitis

Triple-Hormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial

This daily subcutaneous injection established liraglutide as a well studied medication with cardiovascular benefits demonstrated in the LEADER trial