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Second, liquid meals are easier to tolerate

Patients taking oral semaglutide should be instructed to ingest the tablet at least 30 minutes before the first food, beverage, or other oral medications of the day with no more than 4 ounces of plain water only

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This twice daily injectable established the entire drug class

doi: 10.1016/j.jhep.2024.07.006, PMID: [DOI] [PubMed] [Google Scholar] 95

however, this did include some studies in abstract form only, and subsequent further large cohort studies have continued to show an increased risk of poor bowel preparation.40 An abstract from the American College of Gastroenterology meeting in 2024 reported longer gastric transit time and higher rates of incomplete small bowel visualisation in patients taking GLP-1RA undergoing video capsule endoscopy (VCE) when compared with a control group