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Scott Butsch, director of obesity medicine at the Cleveland Clinic in Ohio, told CNN

For patients with depression-related weight gain the bupropion component can improve mood while simultaneously supporting weight loss, making Contrave a strong fit for patients with concurrent depressive symptoms

While earlier research established that GLP-1s suppress appetite and promote weight loss, little was known about their influence on specific food categories and overall dietary behavior

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N Engl J Med 383(15):14361446

Glucagon-like peptide-1 and HPG axis GLP-1 is an intestinal hormone secreted postprandially from the intestinal L cells in the distal ileum and proximal colon in response to nutrients intake