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Description

Both GIPR and GLP-1R belong to the class B family of 7-transmembrane G protein-coupled receptors (GPCR) within the glucagon receptor superfamily (43)

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[14] CCK CCK (cholecystokinin), is a peptide hormone thats critical for bile and digestive enzyme release, nutrient absorption, and suppressing appetite to control food intake

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Under normal circumstances, insulin maintains the NAD(+)/NADH ratio by activating the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway and inhibiting the forkhead box protein O1/heme oxygenase 1 (Foxo1/Hmox1) pathway, thereby mediating the activation of the sirtuin 1/peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (SIRT1/PGC-1) pathway and regulating mitochondrial physiological functions (27)