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Roux-en-Y Gastric-Bypass and sleeve gastrectomy induces specific shifts of the gut microbiota without altering the metabolism of bile acids in the intestinal lumen

Conversely, morphine and -endorphin induced both self-tolerance and cross-tolerance to SM and exenatide [72]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Malik VS, Willet WC, Hu FB

This combination of effects helps people eat less, manage their blood sugar better, and often lose weight, making GLP-1 drugs helpful for both diabetes and weight management

Both reach the same 12mg maintenance dose but on different timelines