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Stenhouse C, Hogg CO, Ashworth CJ

In large clinical trials, tirzepatide demonstrated significant total body weight loss over time

Although the overall risk is low, it is a significant concern

Diarrhea: Affects about 15-20% of patients
Adequate hydration, constipation prevention, proper hygiene, and awareness of symptoms provide robust protection against UTIs during semaglutide treatment

Future multi-receptor therapeutics may need individualized strategies tailored to individual receptor expression profiles or metabolic characteristics
