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Ethics declarations Competing interests M.J.D has acted as a consultant, advisory board member and speaker for Boehringer Ingelheim, Eli Lilly, Novo Nordisk and Sanofi

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If you have struggled with weight loss and tried different diets with only limited success you might be wondering if a GLP-1 agonist such as Semaglutide (Wegovy/Ozempic) or Tirzepatide (Zepbound/Mounjaro) could be right for you

It does this by increasing insulin secretion and reducing the amount of glucose produced by the liver

Updated July 2026 The Ozempic and GLP-1 gastroparesis lawsuits involve claims that manufacturers of GLP-1 medications such as Ozempic, Wegovy, Mounjaro, Rybelsus, Trulicity, Zepbound, and Saxenda failed to adequately warn patients and doctors about the potential risk of developing gastroparesis (i.e., stomach paralysis or delayed gastric emptying), a serious gastrointestinal injury that can cause persistent nausea, vomiting, abdominal pain, bloating, dehydration, malnutrition, hospitalization, or the need for feeding tubes or other invasive treatment

A key unresolved issue is whether direct BBB penetration is required or whether therapeutic effects can arise from circumventricular activation, peripheral metabolic improvement, or systemic immunomodulation
