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Tirzepatide acts on two hormone receptors rather than one, which contributed to the significant weight reduction results seen in the SURMOUNT-1 study
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Ozempic and Wegovy built a $50B market with 15% weight loss

Many stones cause no symptoms, but a stone that blocks the gallbladder outlet can cause severe pain and may lead to cholecystitis, an infection or inflammation of the gallbladder
When stopping GLP-1 prior to surgery, careful consideration is needed due to these medications' effect on gastric emptying, which may increase aspiration risk during anaesthesia

Chronic stimulation may lead to C-cell hyperplasia and eventual tumor formation