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It should be noted that Figure 2 is a simplified representation of the overall approach recommended by the ADA/EASD and includes only recommendations up to the point of dual antihyperglycemic therapy

The far-right column shows the total expenditures for each year, starting at only $188.3 million in 2012 and skyrocketing to $13.91 billion by 2022, an increase of an unbelievable 7,921 percent

Studies are also underway for a spectrum of other conditions, including Phase 3 trials investigating non-alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), and obstructive sleep apnea (OSA), as well as mid-to-late stage trials exploring potential benefits in neurodegenerative disorders like Parkinsons disease

According to WTW data, the PMPM expenditure on these drugs for employers has increased exponentially

Example: Diclofenac SR, Metoprolol SR Controlled Release (CR) The release rate is precisely controlled to maintain a nearly constant plasma concentration (1224 hours)

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