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GLP-1 medications are increasingly used off-label for the obesity and insulin-resistance components of PCOS

The Impact of the Treatments on the Response of -enriched Genes and Proteins In the second part of this study, we investigated the responses of genes and proteins associated with -cell identity, including Ins1 , Ins2 , Pdx1 , Slc2a2 , MafA , NeuroD1 , and Foxo1 mRNA, as well as PDX-1, FOXO1, and NKX6.1 proteins, to 1 mM metformin, 10 nM semaglutide, and the combination of 1 mM metformin and 10 nM semaglutide (MS)

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doi: 10.1046/j.1467-789x.2000.00011.x [DOI] [PubMed] [Google Scholar] 57.LeBlanc ES, OConnor E, Whitlock EP, et al

In rare cases, patients reported blurred vision and confusion

Ketoacidosis is a serious condition and may need to be treated in the hospital