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Findings from research models do not establish safety or efficacy in humans

Older data supports a similar level of change

- Represented by Motley Rice

SURMOUNT-2, which studied participants with type 2 diabetes, showed up to 15.7% mean weight loss with tirzepatide versus 3.3% with placebo

Yerba mate may contribute to a small caloric deficit through increased expenditure, but it cannot replace the sustained appetite reduction and metabolic changes produced by GLP-1 receptor agonism

In addition to GLP-1/GIP/GCG receptors tri-agonists, there are also triagonists targeting Xenopus GLP-1/GCG/Cholecystokinin-2 (CCK2) receptors [107], GLP-1/GCG/ neuropeptide Y 2 receptors [108], and GLP-1R, neuropeptide Y1, and neuropeptide Y2 receptors [109]