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In 2018 Zheng and colleagues compared the efficacy of SGLT-2i, GLP-1 agonists, and DPP4i on mortality and cardiovascular end points using a network meta-analysis of 236 trials with 176 310 participants, finding that SGLT-2 inhibitors were associated with reduction in all MIs [HR 0.86 (95% CI 0.770.97)] and nonfatal MIs [HR 0.84 (95% CI 0.720.98)] compared with the control groups (Zheng et al., 2018)

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