glp-1 function and the kidney: from physiology to pharmacology and outcomes in diabetes Glucagon-Like Peptide-1 Receptor Agonists–Health Professional

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Obesity and type 2 diabetes (T2D) are associated with increased rates of mental disorders, particularly depression, anxiety and binge-eating disorder

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Purpose of Review This review provides a comprehensive and scholarly examination of glucagon-like peptide-1 receptor (GLP-1R) agonists, tracing their evolution from glycemic control agents in diabetes mellitus (DM) to multifaceted therapeutics with expanding indications in cardiovascular, renal, and metabolic health

Recent advancementsincluding the approval of oral semaglutide (Rybelsus)have demonstrated the potential for effective oral peptide delivery, though such formulations still face significant pharmacokinetic and formulation-related challenges