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The Negatives: What the Trials Showed Across programs like STEP, SURMOUNT, and SELECT, side effects were largely gastrointestinal: Nausea, vomiting, constipation, diarrhea

Patients using GLP-1 therapies for weight loss often have different expectations and motivations compared to those using them for diabetes

Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe

The FDA label recommends using additional non-hormonal contraception for 4 weeks after initiating or increasing the dose of tirzepatide

A trending weekly average is the most reliable indicator of actual fat loss

Furthermore, combination therapy trials exploring the synergistic effects of GLP-1RAs with biologics could uncover new approaches for treatment, enhancing the management both metabolic and immunologic aspects in PsA
