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Stewart and Ogden, 2019) and, compelling evidence indicates that maintaining an elevated BMI over the long term significantly increases the risk of developing chronic diseases (Sainsbury and Hay, 2014), body positivity became a robust cultural narrative, encouraging society to respect the dignity of all body sizes and to question the assumption that thinness equates to health (Holi, 2025

A PRISMA flow diagram [6] illustrating the selection process can be found in Fig

Rosenstock J, Wysham C, Fras JP et al (2021) Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

Sustainable weight loss is most likely to be achieved by combining GLP-1 therapy with healthy habits like a nutritious, balanced diet, regular exercise, and adequate sleep

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(3) Multitargeted therapy: BBR-isoliquiritigenin (ISL) dual therapy attenuates adipose inflammation and dyslipidemia via IRS1-PI3K-Akt pathway activation in DIO mouse, while BBR-catechin-capsaicin polypharmacology outperforms monotherapies in 3T3-L1 adipocytes [181, 195]