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Long-term Weight Maintenance : Studies suggest that the combination of GLP-1 agonists and metformin may help individuals achieve sustainable weight loss and prevent weight regain over the long term, especially when used in conjunction with lifestyle modifications such as diet and exercise

GLP-1 medications have been shown to have many benefits in treating obesity and type 2 diabetes

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Lancet 2017

"As we start to age, our bones are going to be weaker and we're going to lose muscle mass, which is going to increase your risk for things such as osteoporosis and even falls," said Shepherd, the author of "Generation M: Living Well in Perimenopause and Menopause." "With diet, you significantly want to increase your protein intake, and [with] exercise, changing those regimens to more of resistance training and weightlifting."

High circulating ghrelin: A potential cause for hyperphagia and obesity in Prader-Willi syndrome