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Background Despite the effectiveness of glucagon-like peptide-1 agonist (GLP-1A) in the treatment of diabetes, its large molecular weight and high hydrophilicity result in poor cellular permeability, thus limiting its oral bioavailability

The use of this medication has become widespread as several celebrities have experienced notable weight loss

Beyond their impact on weight, these medications have shown promise in ameliorating obesity-related health markers, including lowering blood pressure, improving lipid profiles, and enhancing glycemic control (Marso et al., 2016)

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