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While injection-site irritation is well recognized, clinicians are increasingly observing broader skin changes in patients treated with semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound)

Table 2 Summary of the studies about bone metabolism in PWS

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This timeline underscores the importance of managing expectations while these promising compounds progress through the development pipeline, and highlights the need for continued research into alternative treatment options for patients with obesity and related metabolic conditions

Following these initial results, the SOUL trial was commenced to specifically study the efficacy of oral semaglutide on cardiovascular health and find if oral semaglutide can be more beneficial than placebo