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By months three to four, the energy trajectory typically reverses, and many participants describe feeling more energetic than they have in years

doi: 10.1002/SIM.3767

However, this still leaves most individuals substantially below their starting weight

The risk of hypoglycemia increases when used with insulin or sulfonylureas

While the causal relationship between incretin-based therapies and pancreatitis remains debated, postmarketing reports have documented cases of acute pancreatitis in patients receiving GLP-1 receptor agonists
