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Adverse reactions were compared between combination therapy and monotherapy (GLP-1 RAs or metformin alone), followed by stratified analyses by gender, age, and body weight

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The STEP 1 trial showed up to 45% of weight lost on semaglutide was lean mass

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However, their true potential was unlocked when Novo Nordisk evolved early molecules like liraglutide into semaglutide, a more effective, longer-acting drug.