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(Note that on November 19, 2024, the parties filed a joint status report in the case where FDA indicated it has not yet made a determination in its reconsideration of the status of tirzepatide and will provide another update to the court on December 19, 2024

doi: 10.1016/j.cell.2024.06.003 124 RosenkildeMMLindquistPKizilkayaHSGasbjergLS

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The brain, mainly the hypothalamus, integrates these gut-derived signals, along with others, to coordinate the regulation of food intake, energy expenditure, and glucose homeostasis 14,15