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By applying advanced image analysis techniques, we enable accurate quantification of the cells and lesions identified through histological staining, immunohistochemistry (IHC), or immunofluorescent staining

High-risk or unstable patients require close supervision

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PLC hydrolyzes membrane phosphatidylinositol diphosphate into inositol triphosphate (IP3) and diacylglycerol (DAG), 86 resulting in increased cytoplasmic Ca 2+ concentration and PKC activation, increased platelet secretion, and activation of IIb 3 -mediated signaling, triggering a series of intracellular events

Thus, a systematic review of the efficacy of GLP-1RAs in terms of their effect on the underlying pathology of AD and improvement of cognitive functions, which included 6 articles that met the criteria (4 randomized control studies and 2 protocol studies) [53], indicates that GLP-1RA therapy in AD did not alter -amyloid and tau protein biomarkers and did not improve cognitive abilities, but demonstrated potential metabolic and neuroprotective benefits

The Asia-Pacific perspective: redefining obesity and its treatment