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Therefore, localized delivery methods, such as intravitreal implants, nanoparticle carriers, or gene therapy aimed at retinal GLP-1R expression, are essential for maximizing therapeutic effectiveness while minimizing systemic exposure

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[DOI] [PMC free article] [PubMed] [Google Scholar] 186

This prompted Moore's group to study the effects of duodenal extracts given daily by mouth to three patients recently diagnosed with juvenile diabetes (type 1)
