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3 Participants on oral semaglutide lost an average of about 16.6% of their body weight

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This shift occurs because GLP-1 receptors influence dopamine pathways associated with food reward, reducing the pleasure signal from unhealthy eating patterns

doi: 10.1016/j.cmet.2016.06.009 38 ChenJXuSZhouWWuLWangLLiW

Adults with obesity (BMI 30) or overweight (BMI 27) with conditions like hypertension

doi: 10.1038/ijo.2013.162