glp-1 weight loss comparison The Weight-loss Effect of GLP-1RAs Glucagon-Like Peptide-1 Receptor Agonists in Non-diabetic Individuals with Overweight or Obesity: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials Virta Health Announces First-of-its-Kind Peer-Reviewed

Elimination half-lives were adapted from a 2021 review paper by Nauck et al

It produces more modest results than semaglutide or tirzepatide, typically around 8 percent body weight loss, but it was the first GLP-1 to receive FDA approval specifically for weight management and remains a viable option for patients who prefer a shorter-acting medication or who experience intolerable side effects on the more potent formulations

Cost, availability, and insurance coverage differ

Together, these findings necessitate further investigations to ascertain whether coordinated inhibition of NMDA receptors in GLP-1 receptor neurons modulates neuronal activity beyond canonical feeding regions, such as the mesolimbic dopaminergic reward pathway

This journey hasnt been perfect, but its been worth it

Sara Karjoo MD is part of the speaker's bureau for Abbott, Nutricia, Mirum, and Ipsen