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When semaglutide patients switch to tirzepatide In the graph below, you can see that patients who switched from semaglutide to tirzepatide, either because of greater side effects on semaglutide or because they felt they hit a plateau on semaglutide, they continued to lose weight on tirzepatide

Small vessel disease of not only the heart but also the eye is an evolving field of research
found that exenatide increased brain lactate dehydrogenase activity, enhancing anaerobic glucose catabolism in brains of PS1-KI mice (207)

Additionally, semaglutide slows gastric emptying, which prolongs the sensation of fullness after meals and reduces appetite through effects on appetite centers in the brain

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