will doctors prescribe compounded semaglutide Online: Prescribed by Physicians Semaglutide for weight loss |

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doi: 10.1111/jdi.12275

Weight loss with semaglutide injections works well for many people, but this treatment is not suitable for everyone

Most individuals start noticing a gradual reduction in weight after about 4 weeks, with more significant weight loss occurring after 12-16 weeks of consistent use

GLP-1 medications work partly by suppressing appetite and slowing gastric emptying. That's the mechanism behind the weight loss. But less food in means fewer vitamins and minerals in and the research now shows this isn't a theoretical concern. Urbina et al. (2026) found that across 480,825 GLP-1 users, 22% had a new nutritional deficiency diagnosis by 12 months. Vitamin D was most common (13.6%), followed by nutritional anemia (4%), iron deficiency (3.2%), and B vitamin deficiency (2.6%). In a smaller dietary study (Johnson et al. 2025, Frontiers in Nutrition), 64% of GLP-1 users didn't meet iron intake recommendations, and 72% fell short on calcium.* This GLP-1 supplement covers the five most at-risk nutrients with bioavailable forms: methylcobalamin B12, chelated iron, chelated zinc, 5-MTHF folate, and vitamin D3

Contrary to the findings of this research, it was discovered that metformin therapy had no effect on the expression of the GLUT2 gene in enterocytes (Lenzen et al., 1996)