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YOU DONT WANT TO HAVE TO TAKE SOMETHING YOU REALLY DON Dartmouth Health study could point way to sustained weight loss for those who stop using GLP-1 drugs Updated: 5:16 AM EDT May 20, 2026 Editorial Standards GLP-1 drugs have transformed obesity treatment, but many patients regain weight after stopping the medication.Now, researchers at Dartmouth Health are studying a new outpatient procedure they hope could help patients maintain their weight without staying on the drugs forever

Possible mechanisms of renal protection with SGLT2 inhibitors are multifactorial and it is likely that reduction in the glomerular capillary pressure, and reduction in an initial hyperfiltration, can contribute to the reduced albuminuria and prevention of renal impairment [62, 63]

Any potential additive effect could be attributable to differential mechanisms of action of the two classes of medication, and mechanistic interaction was suggested in an experimental study of diabetic mice in which finerenone prevented downregulation of GLP-1 receptors in the kidney (16,25)