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[DOI] [PubMed] [Google Scholar] 50.Sun F, Yu K, Yang Z, Wu S, Zhang Y, Shi L, Ji L, Zhan S

The FDA has granted it Fast Track designation for reviewing and potentially approving it as a weight loss medication for people without diabetes

Recently, chronic ICV infusion of a GLP-1R and glucagon receptor co-agonist has been shown to significantly decrease plasma and liver lipids in a cholesterol-fed hamster model of dyslipidemia

Report No.: NCT06082063

Starting at a low dose and gradually increasing, as the dosing schedule is designed to do, may help manage these effects

The combination of GLP-1 and glucagon agonism increased energy expenditure through thermogenic activation in brown adipose tissue
