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Beyond T2D and weight management in individuals with overweight or obesity, GLP-1 receptor agonists are approved for metabolic dysfunction associated steatohepatitis in people with moderate or advanced fibrosis, obstructive sleep apnea in obese adults, reduction of major adverse cardiovascular events in adults with T2D and cardiovascular disease (CVD), and slowing progression of chronic kidney disease and cardiovascular mortality in adults with both chronic kidney disease and T2D

However, these benefits can vary widely between individuals, making patient selection critical

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[1] [7] Other notable effects include injection site reactions beyond pain (erythema, pruritus, induration in 13% of patients), increased heart rate (particularly with liraglutide), gallbladder disease (including gallstones and cholecystitis), and potential dehydration-related acute kidney injury

Akkermansia works at the gut lining level, helping strengthen the gut barrier and supporting effective guthormone communication for appetite and metabolic balance

PI, MJB, JG and WH were involved in data collection and interpretation, and review of the manuscript