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Pharmacological therapeutics for MAFLD To date, the currently available drugs for MAFLD treatment have been studied in many clinical trials

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This triple mechanism of action distinguishes retatrutide from currently approved medicines such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 receptor agonist)

They require balancing anticipated metabolic gains against timing constraints, discontinuation requirements, and residual uncertainty in reproductive outcomes

Market sizing for these expanded indications has been substantial [18, 29], yielding a very high velocity assessment

It enrolled 17,604 adults aged 45 or older with a body mass index (BMI) of 27 kg/m2 or greater and preexisting CVD (prior MI, prior stroke or peripheral artery disease) without diabetes