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Clinical evidence shows GLP-1 receptor agonists reduce the risk of major adverse cardiovascular events in patients with established cardiovascular disease or multiple risk factors while on treatment

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The mechanisms by which pasireotide exerts these effect have been described in the section on Cushings disease

GLP-1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities

When this happens, it can increase the chances food is aspirated into the lungs or airway during a medical procedure

Thereby, an upregulation of CD68 occurs and initiates a signaling cascade, which might be implicated in the pathogenesis of arthritis, and may be relevant for other inflammatory diseases as well (33)