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Binding of GLP-1 to GLP1R has multiple effects, including enhancing insulin secretion from pancreatic beta cells in response to glucose, increasing insulin expression, preventing beta-cell apoptosis, promoting the formation of new beta cells, reducing glucagon secretion, slowing down stomach emptying, promoting satiety, and improving glucose disposal in peripheral tissues

In addition, a large number of clinical studies have shown that GLP-/GIP dual agonists can reduce LFC, VAT, and body weight, and have an improvement effect on both NAFLD and NASH [131,132]

Expert Opin Pharmacother (2007) 8:2593608

These tools enable real-time visualization of receptor binding and activation, trafficking, and ligand-receptor dynamics in living cells and tissues , dramatically improving the reliability and throughput of drug screening

M., et al

10.1016/j.diabres.2021.108935 Diabetes Res Clin Pract