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A Network Meta-Analysis In this intriguing study, researchers led by Thomas Karagiannis analyzed data from 22 RCTs of tirzepatide and semaglutide in 18,472 patients with type 2 diabetes

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Clinical trials of tirzepatide showed average weight reductions of 1522% over 68 weeks at maximum doses, substantially higher than single-agent GLP-1 therapies

Diagnoses: All 3 patients had severe dryness in the mouth with minimal frothy saliva with mean modified Schirmer test of 9 mL at 3 minutes (range 810 mL)

This level produced only minimal weight loss effects
