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Semaglutide works by activating GLP-1 receptors in the brain and digestive system to reduce hunger and slow stomach emptying, but this mechanism occurs alongside whatever thyroid-related metabolic state you already have

Impacting Brain Signals: GLP-1s also act on appetite centers in the brain, helping to reduce hunger and cravings

The enhanced insulin responses and reductions in NEFA were observed without significant hypoglycemia

Semaglutide is a diabetes medication commonly used to treat diabetes

However, current fluorescent imaging techniques may underestimate brain penetrance, and better techniques will be needed to get a fuller picture of which GLP-1 receptors are reached by systemically administered GLP-1R agonists
