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Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimers disease: link to brain reductions in acetylcholine

doi: 10.2337/dc15-1995

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inflammation is characterized by the production of large amounts of proteins, such as cytokines or chemokines and, furthermore, studies using mice deficient in ER UPR-mediators link ER stress in the highly secretory subtypes of IEC, antimicrobial peptides-producing Paneth cells and mucin-producing goblet cells, with antimicrobial defense and intestinal inflammation (117119)