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Your provider has several levers to pull: slowing down your dose titration, adjusting your dose, fine-tuning your meal plan, or in some cases discussing a different medication

Understanding the fundamentals of peptide chemistry and how peptides work at the molecular level helps you appreciate why these seemingly technical details have practical consequences for your results

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Puede ser necesario ajustar la dosis de Ozempic en funcin de la respuesta del paciente y la aparicin de efectos secundarios

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### How Each Drug Performs at Key Milestones | Milestone | Orforglipron (36 mg) | Oral Semaglutide (50 mg) | Tirzepatide (15 mg) | |-----------|---------------------|-------------------------|---------------------| | **4 weeks** | ~2-3% | ~2-3% | ~3-4% | | **12 weeks** | ~6-8% | ~6-7% | ~8-10% | | **24 weeks** | ~10-12% | ~10-11% | ~14-16% | | **36 weeks** | ~14-15% | ~12-13% | ~17-19% | | **68-72 weeks** | ~15%+ (projected) | ~15.1% | ~20-22.5% | For detailed semaglutide weight loss trajectories, see our [semaglutide weight loss results timeline](/guides/semaglutide-weight-loss-results-timeline-what-to-expect)