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One of the major side effects is the change in taste perception

Bone health should be considered during significant weight loss, particularly in older adults or those with osteoporosis risk factors

This prevents the breakdown of dietary fats into free fatty acids and monoglycerides that can be absorbed, leading to a reduction in caloric intake and weight loss [24]

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Depressed patients are often characterized by elevated blood cortisol levels and changes in the circadian secretion of this hormone, an increased number of corticotropin-releasing hormone (CRH)-expressing neurons in the hypothalamic paraventricular nucleus (PVN), as well as an impairment in a negative feedback mechanism, which can be measured in the dexamethasone suppression test [70, 71]

The most common side effects include nausea, diarrhea, constipation, and fatigue, especially in the first few weeks of treatment