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Because GLP-1 medications already slow gastric emptying, consuming fatty meals can exacerbate this effect
Moreover, because GLP-1R is expressed throughout the body, stimulation with a GLP-1R agonist or indirectly with a DPP-IV inhibitor can have a broad systemic effect on systemic metabolism, which, in turn, ameliorates peripheral and central insulin resistance in AD and MD (Athauda and Foltynie, 2016)
As appetite decreases, thirst signals may also become less noticeable, making it easier to unintentionally drink less water throughout the day
Given the narrative nature of this review, a double-blind screening process was not applied, which is acknowledged as a limitation
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