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retatrutide phase 2 results obesity nejm 2023 in adults with over 104 weeks in the highest dose group had 30.3% weight loss. Nearly 2/3 reached BMI < 30 1 in 3 reached BMI < 25 Phase 2 Trial of Retatrutide
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These are long-term medications to help with overall survival and to help with your cardiovascular fitness

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What changes did you see, and how did you handle them

They also explored the biochemical alterations underlying metabolic changes in the participants

For the deep dives, see What Is CagriSema