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During in vivo assays, in addition to the natural biodegradation of PLGA for metformin release, iontophoresis was used to force metformin permeation through the dermal layer and reach subcutaneous WAT

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It has been shown that GLP-1 analogue exenatide could activate the human monocyte-derived macrophage towards M2 phenotype (29)

Timing considerations add complexity

Se observ una reduccin en el riesgo de trastornos neurocognitivos como el Alzheimer y la demencia, as como una menor incidencia de convulsiones y adiccin a sustancias como el alcohol, cannabis, estimulantes y opioides

Kudos to the team for running the study but also publishing 'negative' data