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In obesity, adipocytes and immune cells residing in adipose tissue secrete many proinflammatory factors including tumor necrosis factor (TNF) and interleukin 6 (IL-6), which impact adipose tissue function and produce systemic effects via activation of stress kinases to promote insulin resistance [50,51]

10.1038/s42255-019-0095-y [DOI] [PubMed] [Google Scholar] 30.Ye, R

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