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The most consistent lipid change observed with GLP-1 therapy is a reduction in triglycerides , typically ranging from 10-20% in clinical studies

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A broader PMC review on resistant starch and the gut microbiome (PMC10819196) documented the SCFA-mediated appetite-regulating pathway, noting that RS fermentation stimulates PYY and GLP-1 release, leading to increased satiety and reduced caloric intake in studied models

On-target and off-target analysis by amplicon sequencing Liver genomic DNA from in vivo knock-in experiments with Balb/c mice was analyzed for on-target and off-target effects using amplicon sequencing on a MiSeq platform (Illumina)