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This head-to-head comparison suggests potential superiority of GLP-1 RAs over SGLT2 inhibitors for liver-related outcomes, although both medication classes demonstrate metabolic benefits

The newest kid on the block The ATTAIN-2 trial was conducted across 10 countries and involved more than 1,600 people who were obese or overweight with type 2 diabetes

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Semaglutide also significantly reduces macrophage activity in adipose tissue and decreases the levels of inflammatory mediators NF-kB together with JNK activation [22,35,153]

Moreover, probiotics primarily modulate gut microbiota, which produce an array of metabolites
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