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When starting GLP-1 RAs, these findings suggest the need for individualized medicine strategies, which may include careful patient selection, risk-benefit analyses, and possibly introducing earlier or more frequent colorectal cancer screening for high-risk patients

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However, in subjects with or without pre-existing HF symptoms, linagliptin and sitagliptin had a neutral effect

[61] Research continued, and in 1993, Michael Nauck managed to infuse GLP-1 into people with type 2 diabetes, stimulating insulin while inhibiting glucagon and bringing blood glucose to normal levels

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