glp 1 updates Glucagon-like peptide-1 receptor: mechanisms and advances in therapy GLP-1 Clinical Practice Updates: February

One monkey from the AMG 133 0.25 mg kg 1 group and two monkeys from the AMG 133 0.75 mg kg 1 group were excluded from the study/data analysis due to loss of exposure (antidrug antibody-mediated clearance)

Suppressing glucagon secretion: It inhibits glucagon, a hormone that otherwise raises blood glucose levels

Growth/differentiation factor-15 (GDF-15) is a stress-induced cytokine expressed in multiple cell types, including cardiomyocytes, adipocytes, and macrophages

GLP-1 medications include drugs such as Ozempic, Wegovy, Mounjaro, and Zepbound

Most long-acting injectable GLP-1 receptor agonists can be administered with or without food there is no requirement to take them on an empty stomach

Hippen: I want to pivot a little bit to talk about the FLOW trial which was we learned was recently stopped early