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The pathogenesis of diabetes is primarily driven by hyperglycemia and insulin deficiency (82)

The FTO gene (rs9939609) and MC4R gene (rs17782313) variants also affect baseline metabolic rate and appetite regulation, potentially modulating how severely side effects manifest and how quickly appetite suppression becomes tolerable

With the goal of enhancing patient outcomes and enabling practitioners to overcome physician supply shortages, there is an urgent need to explore new pharmacologic therapies that target mechanisms of neuro-ophthalmic degeneration

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