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Although the pathophysiology of cisplatin-induced cognitive impairment (CICI) has not been fully elucidated, several pathophysiologic mechanisms, including oxidative stress, inflammation, mitochondrial dysfunction, DNA damage, and apoptosis, have been proposed as possible explanations ( Many studies have shown that cisplatin-induced mitochondrial damage in cells leads to oxidative stress and neuronal damage that results in cognitive impairment (CICI) (Taanman, 1999)
At the time, they were 8 and 10
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Yes, but do it carefully
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